CAS : 1111-97-3
UN# : UN1993
MDL : MFCD00190221
Hazard Class : 3
EINECS : 214-188-9
Packing Group : II
Other name :
1,1-Dimethylpropargyl chloride
Chemical Properties
Formula : C5H7Cl
Formula weight : 102.57
Melting Point : -61°
Boiling Point : 73-75°
Flash point : 4°(40°F)
Density : 0.913
Refractive Index : 1.4178
Sensitivity : Keep Cold.
Form : Liquid
Literature References
Reagent for an improved 2-step introduction of the 1,1-dimethylallyl (DMA) ester protecting group for carboxylic acids. Reaction with the acid in the presence of copper(I) iodide and cesium carbonate in DMF affords the 1,1-dimethylpropargyl ester. Hydrogenation with Pd/barium sulfate/quinoline affords the 1,1-dimethylallyl ester. The DMA group is resistant to nucleophilic attack, but readily cleaved under non-acidic conditions with Pd(0), which is an advantage compared with the tert-butyl ester in solid-phase peptide synthesis: Org. Lett., 7, 1473 (2005).
Notes
Other References:UN#: UN1993
Grade Specifications
Grade Specifications
Hazard Statements : H225-H315-H319-H335Highly flammable liquid and vapour.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P210-P241-P303+P361+P353-P305+P351+P338-P405-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.Use explosion-proof electrical/ventilating/lighting/ equipment.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
| Pakage | 1g, 25g, 5g |
|---|---|
| brand | Alfa Aesar |
