[H29041] CAS 114360-54-2 | N-Fmoc-D-leucine, 98% | Alfa
0 ₩
Brand: Alfa Aesar
114360-54-2 | C21H23NO4 | (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-methylpentanoic acid
Chemical Identifiers
CAS
114360-54-2
Molecular Weight (g/mol)
353.42
MDL Number
MFCD00062957
Synonym
(2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-methylpentanoic acid
SMILES
CC(C)C[C@@H](NC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)C(O)=O
InChI Key
CBPJQFCAFFNICX-TWYLJJHKNA-N
Molecular Formula
C21H23NO4
IUPAC Name
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoic acid
Specifications
Appearance (Color)
White to pale cream
Melting Point (clear melt)
150.0-157.0?C
Form
Powder
Assay (Aqueous acid-base Titration)
≥97.5 to ≤102.5%
Optical Rotation
24.5 ± 1.0? (C=1 in DMF)
설명
A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline where the condensation between L-tryptophan methyl ester and N-Fmoc-D-leucine in the presence of EDC as coupling agent afforded the corresponding L-Trp-D-Leu dipeptide.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline where the condensation between L-tryptophan methyl ester and N-Fmoc-D-leucine in the presence of EDC as coupling agent afforded the corresponding L-Trp-D-Leu dipeptide.
A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline where the condensation between L-tryptophan methyl ester and N-Fmoc-D-leucine in the presence of EDC as coupling agent afforded the corresponding L-Trp-D-Leu dipeptide.
Solubility
Insoluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
GHS Hazard and Precautionary Statements
Hazard Statements:
Risk & Safety
TSCA:No
경고:RUO – Research Use Only
CAS114360-54-2FORMULAC21H23NO4MDLMFCD00062957
| Pakage | 1g, 25g, 5g |
|---|---|
| brand | Alfa Aesar |
