[H52792] CAS 75330-75-5 | Lovastatin, 97% | Alfa
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Brand: Alfa Aesar
75330-75-5 | H52792
Chemical Identifiers
Specifications
Chemical Name or Material
Lovastatin
CAS
75330-75-5
Melting Point
175°C
Recommended Storage
Ambient temperatures
RTECS Number
EK7907000
설명
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.
Solubility
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.
GHS Hazard and Precautionary Statements
Hazard Statements:H317-H351-H361d
GHS H StatementH302-H315-H319-H335 Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements:P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c
Risk & Safety
TSCA:NoRTECS Number:EK7907000
경고:RUO – Research Use Only
CAS75330-75-5MDLMFCD00072164
| Pakage | 25g, 5g |
|---|---|
| brand | Alfa Aesar |
