[J60155] CAS 78111-17-8 | Okadaic acid, 98%

CAS : 78111-17-8
UN# : UN2811
MDL : MFCD00083455
Hazard Class : 6.1
Packing Group : II

Chemical Properties

Formula : C44H68O13
Formula weight : 805.02
Sensitivity : Store at -20°C.
Form : Powder
Solubility : It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.

Applications

Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.Other References :
Merck : 14,6819
UN# : UN2811

GHS Hazard and Precautionary Statements

Hazard Statements : H300-H310-H330-H315Fatal if swallowed.Fatal in contact with skin.Fatal if inhaled.Causes skin irritation.
Precautionary Statements : P260-P301+P310-P304+P340-P320-P330-P361-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Specific treatment is urgent (see label).Rinse mouth.Remove/Take off immediately all contaminated clothing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
위험 문구 : 23/24/25-38Toxic by inhalation, in contact with skin and if swallowed.Irritating to skin.
안전 문구 : 4-9-20-27-36/37/39-45-60Keep away from living quarters.Keep container in a well-ventilated place.When using do not eat or drink.Take off immediately all contaminated clothing.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste