[J61072] CAS 64-86-8 | Colchicine, 98% | Alfa
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Brand: Alfa Aesar
64-86-8 | C22H25NO6 | colchicine colchicine, its salts and derivatives colchicina colchicin colchicinum condylon (S)-colchicine 7alphah-colchicine
Chemical Identifiers
CAS
64-86-8
Molecular Weight (g/mol)
399.44
Synonym
colchicine colchicine, its salts and derivatives colchicina colchicin colchicinum condylon (S)-colchicine 7alphah-colchicine
SMILES
COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
InChI Key
IAKHMKGGTNLKSZ-INIZCTEOSA-N
Molecular Formula
C22H25NO6
IUPAC Name
N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0²,⁷]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
Specifications
Form
Powder
Appearance (Color)
White to pale yellow
Comment
Solubility: DMSO 25mg/ml, Ethanol 25mg/ml
Assay from Supplier’s CofA
≥97.5%
Proton NMR
Conforms to structure
설명
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.
Notes
Light sensitive. Incompatible with oxidizing agents.
Other References:
Merck Index:14,2471UN Number:UN1544Beilstein:2228813
GHS Hazard and Precautionary Statements
Hazard Statements:H300-H340
GHS H StatementH300-H340 Fatal if swallowed.May cause genetic defects.
Precautionary Statements:P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
Risk & Safety
TSCA:YesRTECS Number:GH0700000
경고:RUO – Research Use Only
CAS64-86-8FORMULAC22H25NO6HAZARD CLASS6.1EINECS200-598-5MDLMFCD00078484,MFCD00078484PACKAGING GROUPI
| Pakage | 1g, 500MG, 5g |
|---|---|
| brand | Alfa Aesar |
