[J61286] CAS 14611-52-0 | (R)-(-)-Deprenyl hydrochloride

CAS : 14611-52-0
MDL : MFCD00069299

Other name :

Selegiline

Chemical Properties

Formula : C13H17N•HCl
Formula weight : 223.74
Sensitivity : Ambient temperatures.
Form : Crystalline Powder
Solubility : Soluble in water at 100mM

Applications

(R)-(-)-Deprenyl hydrochloride provides neuroprotection which may be relevant to ParkinsonÂ’s disease, AlzheimerÂ’s disease, HuntingtonÂ’s disease, and stroke. It is an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. It demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. It also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H315-H319Causes skin irritation.Causes serious eye irritation.
Precautionary Statements : P280-P305+P351+P338-P302+P352-P321-P362-P332+P313Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Take off contaminated clothing and wash before reuse.If skin irritation occurs: Get medical advice/attention.

Other References :

Merck : 14,8428