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[J61349] CAS 28643-80-3 | Nigericin sodium salt, 98+% | Alfa

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Brand: Alfa Aesar

28643-80-3 | C40H67NaO11 | sodium 2-[(3S,6R)-6-{[(5R,7R,9R,10R)-2-[(3’S,5’R)-5′-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-2,3′-dimethyl-[2,2′-bioxolan]-5-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl}-3-methyloxan-2-yl]propanoate

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설명

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Chemical Identifiers

CAS
28643-80-3
Molecular Weight (g/mol)
746.96
Synonym
sodium 2-[(3S,6R)-6-{[(5R,7R,9R,10R)-2-[(3’S,5’R)-5′-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-2,3′-dimethyl-[2,2′-bioxolan]-5-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl}-3-methyloxan-2-yl]propanoate
SMILES
[Na+].CO[C@@H]1C[C@@H](C[C@H]2CC[C@H](C)C(O2)C(C)C([O-])=O)O[C@]2(OC(C)(CC2C)C2CCC(C)(O2)C2O[C@H](C[C@@H]2C)[C@H]2O[C@@](O)(CO)[C@H](C)C[C@@H]2C)[C@@H]1C
InChI Key
MOYOTUKECQMGHE-KKCUGXASSA-M
Molecular Formula
C40H67NaO11
IUPAC Name
sodium 2-[(3S,6R)-6-{[(5R,7R,9R,10R)-2-[(3’S,5’R)-5′-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-2,3′-dimethyl-[2,2′-bioxolan]-5-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl}-3-methyloxan-2-yl]propanoate

Specifications

Assay by NMR
Conforms to structure
Appearance (Color)
White to pale yellow
Form
Powder
Assay from Supplier’s CofA
≥ 98%

설명

Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

Solubility
Soluble in chloroform, methanol or ethanol

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents, acids, bases and heat.

Other References:

Merck Index:14,6541UN Number:UN3462Beilstein:3892398

GHS Hazard and Precautionary Statements

Hazard Statements:H301-H315-H319-H335
GHS H StatementH301-H315-H319-H335 Toxic if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements:P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c

Risk & Safety

TSCA:NoRTECS Number:QT6840000

경고:RUO – Research Use Only

CAS28643-80-3FORMULAC40H67NaO11HAZARD CLASS6.1MDLMFCD00036825PACKAGING GROUPIII

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Pakage

10MG, 50mg
brand

Alfa Aesar
SKU: J61349 Category:  Brand:
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[J61349] CAS 28643-80-3 | Nigericin sodium salt, 98+% | Alfa

[J61349] CAS 28643-80-3 | Nigericin sodium salt, 98+% | Alfa

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