[J61491] CAS 1397-89-3 | Amphotericin B, Streptomyces nodosus

CAS : 1397-89-3
MDL : MFCD00877763
EINECS : 215-742-2

Chemical Properties

Formula : C47H73NO17
Formula weight : 924.10
Sensitivity : Keep Cold. Moisture Sensitive. Light Sensitive.
Form : Powder
Solubility : Soluble in aqueous buffers at pH 2.0 or 11.0. Insoluble at pH 6.0-7.0. Also soluble in DMSO or DMF

Applications

Amphotericin B, antifungal activity has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.Other References : Beilstein: 78342
Merck : 14,585

GHS Hazard and Precautionary Statements

Hazard Statements : H315-H319-H335Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P305+P351+P338-P302+P352-P321-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
위험 문구 : 36/37/38Irritating to eyes, respiratory system and skin.
안전 문구 : 26-37-60In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste