[J62362] CAS 59721-29-8 | Camostat methanesulfate, 98%

CAS : 59721-29-8
UN# : UN3077
MDL : MFCD00941410
Hazard Class : 9
Packing Group : III

Other name :

Camostat mesylate

Chemical Properties

Formula : C20H22N4O5.CH3SO3H
Formula weight : 494.52
Melting Point : 164-168°
Sensitivity : Keep Cold.
Form : Powder
Solubility : Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).

Applications

It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H315-H319-H335-H303Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.May be harmful if swallowed.
Precautionary Statements : P261-P305+P351+P338-P302+P352-P321-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References :

Merck : 14,1728
UN# : UN3077