CAS : 127191-97-3
MDL : MFCD00083180
Chemical Properties
Formula : C38H35N5O6S2
Formula weight : 721.84
Melting Point : 65-67°
Sensitivity : Store at -20°C.
Form : Powder
Solubility : Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.93 mg/ml), methanol (10 mg/ml), DMSO (12 mg/ml), chloroform (20 mg/ml), ethanol (~1 mg/ml), 1:2 DMF:PBS (pH 7.2) (~0.3 mg/ml), and DMF & DMSO (~30 mg/ml).
Applications
It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.
GHS Hazard and Precautionary Statements
Hazard Statements :
Precautionary Statements :
위험 문구 :
안전 문구 :
TSCA : 예아니오
RTECS :
| Pakage | 10MG, 1mg |
|---|---|
| brand | Alfa Aesar |
