[J62609] CAS 15307-79-6 | Diclofenac sodium salt | Alfa
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Brand: Alfa Aesar
15307-79-6 | J62609
Chemical Identifiers
CAS
15307-79-6
Specifications
Appearance (Color)
White
Assay from Supplier’s CofA
≥97.5%
Form
Powder
설명
Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
Solubility
Soluble in water (50 mg/ml), PBS pH 7.2 (6 mg/ml), ethanol (∼35 mg/ml), DMF (∼35 mg/ml), DMSO (∼35 mg/ml), methanol (>24 mg/ml), and acetone (6 mg/ml).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
Other References:
Merck Index:14,3081UN Number:UN2811
GHS Hazard and Precautionary Statements
Hazard Statements:H301
GHS H StatementH301-H361 Toxic if swallowed.Suspected of damaging fertility or the unborn child.
Precautionary Statements:P264b-P270-P301+P310-P330-P501c
Risk & Safety
TSCA:NoRTECS Number:AG6330000
경고:RUO – Research Use Only
CAS15307-79-6HAZARD CLASS6.1EINECS239-346-4MDLMFCD00082251PACKAGING GROUPIII
| Pakage | 100g, 25g, 5g |
|---|---|
| brand | Alfa Aesar |
