CAS : 120685-11-2
MDL : MFCD12828879
Other name :
PKC4124′-N-Benzoylstaurosporine
Chemical Properties
Formula : C35H30N4O4
Formula weight : 570.64
Melting Point : 235-260°
Sensitivity : Store at -20°C.
Form : Powder
Solubility : Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).
Applications
Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Due to this act which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
Grade Specifications
GHS Hazard and Precautionary Statements
Hazard Statements :
Precautionary Statements :
Other References :
Merck : 14,6185
| Pakage | 1mg, 5mg |
|---|---|
| brand | Alfa Aesar |
