[J63075] Methotrexate | Alfa
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Brand: Alfa Aesar
| C20H22N8O5 | methotrexate ledertrexate hdmtx arbitrexate methotrexatum 甲氨蝶呤 abitrexate antifolan MTX folex
Chemical Identifiers
CAS
59-05-2
Molecular Weight (g/mol)
454.45
Synonym
methotrexate ledertrexate hdmtx arbitrexate methotrexatum 甲氨蝶呤 abitrexate antifolan MTX folex
SMILES
CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI Key
FBOZXECLQNJBKD-ZDUSSCGKSA-N
Molecular Formula
C20H22N8O5
IUPAC Name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Specifications
Assay (unspecified)
95.0% min.
설명
Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis. It is used as an anticancer drug.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light
Other References:
Merck Index:14,5985UN Number:UN1544
GHS Hazard and Precautionary Statements
Hazard Statements:H301-H315-H319-H335-H340-H360FD
GHS H StatementH301-H360-H315-H319 Toxic if swallowed.May damage fertility or the unborn child.Causes skin irritation.Causes serious eye irritation.
Precautionary Statements:P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c
Risk & Safety
TSCA:YesRTECS Number:MA1225000
경고:RUO – Research Use Only
CAS59-05-2FORMULAC20H22N8O5HAZARD CLASS6.1EINECS200-413-8MDLMFCD00150847PACKAGING GROUPIII
| Pakage | 100mg, 1g |
|---|---|
| brand | Alfa Aesar |
