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[J63361] CAS 1115-70-4 | 1,1-Dimethylbiguanide hydrochloride | Alfa

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Brand: Alfa Aesar

1115-70-4 | C4H12ClN5 | hydrogen metformin (inn) and its salts chloride

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설명

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Chemical Identifiers

CAS
1115-70-4
Molecular Weight (g/mol)
165.63
Synonym
hydrogen metformin (inn) and its salts chloride
SMILES
[H+].[Cl-].CN(C)C(=N)N=C(N)N
InChI Key
OETHQSJEHLVLGH-UHFFFAOYSA-N
Molecular Formula
C4H12ClN5
IUPAC Name
hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride

Specifications

Appearance (Color)
White
Form
Crystalline powder
Assay (Titration)
97% min.
Proton NMR
Conforms to structure

설명

1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1

• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes

• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells

• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway

• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders

• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell

Other References:

Merck Index:14,5938

GHS Hazard and Precautionary Statements

Hazard Statements:H302-H315-H319-H335
GHS H StatementH302-H315-H319 Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.
Precautionary Statements:P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c

Risk & Safety

TSCA:NoRTECS Number:DU1800000

경고:RUO – Research Use Only

CAS1115-70-4FORMULAC4H12ClN5EINECS214-230-6MDLMFCD00012582

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Pakage

100g, 25g, 5g
brand

Alfa Aesar
SKU: J63361 Category:  Brand:
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[J63361] CAS 1115-70-4 | 1,1-Dimethylbiguanide hydrochloride | Alfa

[J63361] CAS 1115-70-4 | 1,1-Dimethylbiguanide hydrochloride | Alfa

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