[L00183] CAS 10416-59-8 | N,O-Bis(trimethylsilyl)acetamide, 95%

CAS : 10416-59-8
UN# : UN2920
MDL : MFCD00008270
Hazard Class : 8
EINECS : 233-892-7
Packing Group : II

Other name :

BSA

Chemical Properties

Formula : C8H21NOSi2
Formula weight : 203.43
Melting Point : -24°
Boiling Point : 71-73°/35mm
Flash point : 42°(107°F)
Density : 0.829
Refractive Index : 1.4170
Sensitivity : Keep Cold. Moisture Sensitive.
Form : Liquid
Solubility : Miscible with many nonpolar and polar aprotic solvents.

Literature References

Powerful silylation reagent for a wide range of functional groups under mild conditions. See Appendix 4. Reviews: J. Prakt. Chem./ Chem. Ztg., 337, 332 (1995); Synthesis, 357 (1998). Unlike halosilanes, silylated amides often need no added base catalysts. For an example of use without added solvent or catalyst for the silylation of a tertiary ɑ-hydroxy ketone, see: Org. Synth. Coll., 7, 381 (1990). Silylating power can be increased in polar solvents such as DMF or acetonitrile, or by addition of acidic catalysts, often TMS chloride, or an acid such as TFA or HCl. O-Silylation in the presence of TBAF (0.02 equiv.) occurs under very mild conditions: Tetrahedron Lett., 35, 8409 (1994). BSA catalyzes the acylation of acylphosphoranes with activated derivatives of carboxylic acids. Subsequent ozonolysis, or oxidation with singlet oxygen or dimethyldioxirane, provides a route to 1,2,3-triketones: J. Org. Chem., 54, 2785 (1989); 60, 8231 (1995):

Notes

Air and moisture sensitive. Incompatible with strong oxidizing agents, water and acids.Other References:Beilstein: 1306669UN#: UN2920

Grade Specifications

Grade Specifications

Hazard Statements : H301-H314-H318-H226Toxic if swallowed.Causes severe skin burns and eye damage.Causes serious eye damage.Flammable liquid and vapour.
Precautionary Statements : P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.