[L02502] CAS 603-35-0 | Triphenylphosphine, powder, 99%

CAS : 603-35-0
MDL : MFCD00003043
EINECS : 210-036-0

Other name :

TPP

Chemical Properties

Formula : (C6H5)3P
Formula weight : 262.29
Melting Point : 79-81°
Boiling Point : 360°
Flash point : 181°(358°F)
Density : 1.200
Sensitivity : Ambient temperatures.
Form : Powder
Solubility : Soluble in ether, benzene, carbon tetrachloride, glacial acetic acid, acetone, chloroform and alcohol. Insoluble in water.

Literature References

Finds widespread use as a complexing agent with transition metals, either in the preparation of stable complexes, or as an additive in metal-promoted reactions. See also Tri(o-tolyl)­phosphine, A12093 and Tri(2-furyl)­phosphine, L13329. Azides can be converted selectively to amines, in the presence of ester, epoxide or nitro groups, by reduction to iminophosphoranes (Staudinger reaction), followed by hydrolysis. For reviews, see: Tetrahedron, 37, 437 (1981); 48, 1353 (1992): In suitable circumstances, the iminophosphorane may undergo intramolecular aza-Wittig reaction: Tetrahedron, 45, 6375 (1989): Reviews: Aza-Wittig reaction in heterocyclic synthesis: Org. Prep. Proced. Int., 24, 209 (1992); Iminophosphoranes as building blocks for the preparation of N-containing heterocycles: Synthesis, 1197 (1994). For use in peptide and other coupling reactions, see 2,2′-Dipyridyl­ disulfide, A11118. For use in the Mitsunobu reaction for conversion of alcohols to alkylating agents, see N-Guanyl­urea sulfate, A19106, and Diisopropyl­ azodicarboxyl­ate, L10386. See also 1,2-Bis(diphenyl­phosphino)­ethane, A11419.

Notes

Incompatible with oxidizing agents and acids.Other References:Beilstein: 610776Merck: 14,9743

Grade Specifications

Grade Specifications

Hazard Statements : H302-H317-H413Harmful if swallowed.May cause an allergic skin reaction.May cause long lasting harmful effects to aquatic life.
Precautionary Statements : P261-P280-P302+P352-P321-P301+P312-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.Dispose of contents/container in accordance with local/regional/national/international regulations.