CAS : 108-77-0
UN# : UN2670
MDL : MFCD00006046
Hazard Class : 8
EINECS : 203-614-9
Packing Group : II
Other name :
TCT2,4,6-Trichloro-1,3,5-triazine
Chemical Properties
Formula : C3Cl3N3
Formula weight : 184.41
Melting Point : 145-149°
Boiling Point : 192-194°
Flash point : >190°(374°F)
Density : 1.920
Sensitivity : Keep Cold. Moisture Sensitive. Store under Nitrogen.
Form : Powder
Solubility : Soluble in acetone, diethyl ether, dioxane, chloroform, carbon tetrachloride and ketones. Slightly soluble in methanol. Insoluble in cold water.
Literature References
In the presence of triethylamine, carboxylic acids are converted to their acid chlorides, allowing in situ formation of esters, amides and peptides: Tetrahedron Lett., 20, 3037 (1979). Similarly, sulfonic acids are converted to sulfonyl chlorides: Tetrahedron Lett., 44, 1499 (2003). ω-Hydroxy acids are converted to their lactones: Tetrahedron Lett., 21, 1893 (1980). Mild reagent in ß-lactam synthesis: Synthesis, 209 (1981). Carboxylic acids, including N-Boc, -Fmoc and -Cbz amino acids have been converted to alcohols in good yield by activation with cyanuric chloride and N-methylmorpholine (NMM), followed by reduction with aqueous NaBH4: Tetrahedron Lett., 40, 4395 (1999). Hydroxamic acids can also be prepared in a simple one-flask method using hydroxylamine hydrochloride in the presennce of NMM and DMAP: Org. Lett., 5, 2715 (2003). Effects deoxygenation of diaryl sulfoxides. Alkyl sulfoxides undergo ɑ-chlorination, which can be avoided by using cyanuric fluoride: Synthesis, 221 (1980). For use, in combination with DMSO, in a mild and efficient alternative to the Swern oxidation of alcohols to aldehydes or ketones, see: J. Org. Chem., 66, 7907 (2001). Reagent for dehydration of aldoximes: J. Chem. Soc., Chem. Commun., 1226 (1972), and primary carboxamides: Synthesis, 657 (1980) to nitriles. The Vilsmeier-type complex with DMF also converts aldoximes cleanly to nitriles; ketoximes undergo the Beckmann rearrangement at room temperature in high yield: J. Org. Chem., 67, 6272 (2002). The complex converts primary and secondary alcohols to alkyl chlorides in high yield; addition of NaBr affords mainly the alkyl bromide: Org. Lett., 4, 553 (2002); whereas with 4 eq. of LiF, primary alcohols are selectively formylated, providing a mild and convenient method for their protection: J. Org. Chem., 67, 5152 (2002). For a brief feature on uses of the reagent in synthesis, see: Synlett, 2156 (2006).
Notes
Air and moisture sensitive. Store in a cool place. Incompatible with strong oxidizing agents, strong acids, alcohols, dimethylformamide, amines and dimethyl sulfoxide.Other References:Beilstein: 124246UN#: UN2670
Grade Specifications
Grade Specifications
Hazard Statements : H330-H302-H317-H314Fatal if inhaled.Harmful if swallowed.May cause an allergic skin reaction.Causes severe skin burns and eye damage.
Precautionary Statements : P260-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment is urgent (see label).Rinse mouth.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
| Pakage | 1000g, 250g, 50G |
|---|---|
| brand | Alfa Aesar |
