[L08855] CAS 540-88-5 | tert-Butyl acetate, 99%

CAS : 540-88-5
UN# : UN1123
MDL : MFCD00008807
Hazard Class : 3
EINECS : 208-760-7
Packing Group : II

Other name :

Acetic acid tert-butyl ester

Chemical Properties

Formula : C6H12O2
Formula weight : 116.16
Melting Point : -62°
Boiling Point : 94-96°
Flash point : 4°(39°F)
Density : 0.863
Refractive Index : 1.3865
Sensitivity : Ambient temperatures.
Form : Liquid
Solubility : Miscible with ether and ethanol. Immiscible with water.

Literature References

Amino acids can be protected as their t-butyl esters, without prior N-protection, in the presence of perchloric acid in 1,4-dioxane: Liebigs Ann. Chem., 646, 134 (1961); or tosic acid and excess sulfuric acid: Org. Prep. Proced. Int., 18, 13 (1986). See Appendix 6. Mild transesterification of, e.g. methyl esters to the t-butyl analogues in the presence of catalytic KO-t-Bu has been reported: J. Org. Chem., 62, 8240 (1997). For lithiation with LDA and addition to acetone in quantitative yield, see: J. Am. Chem. Soc., 95, 3050 (1973). Coupling of the lithio-derivative with esters gives high yields of t-butyl 3-oxoalkanoates: Synthesis, 45 (1985).

Notes

Incompatible with oxidizing agents.Other References:Beilstein: 1699506Merck: 14,1537UN#: UN1123

Grade Specifications

Grade Specifications

Hazard Statements : H225Highly flammable liquid and vapour.
Precautionary Statements : P210-P241-P280-P303+P361+P353-P403+P235-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.Use explosion-proof electrical/ventilating/lighting/ equipment.Wear protective gloves/protective clothing/eye protection/face protection.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.Store in a well-ventilated place. Keep cool.Dispose of contents/container in accordance with local/regional/national/international regulations.