CAS : 288-47-1
UN# : UN1993
MDL : MFCD00005315
Hazard Class : 3
EINECS : 206-021-3
Packing Group : III
Chemical Properties
Formula : C3H3NS
Formula weight : 85.13
Melting Point : -33°
Boiling Point : 117-118° Flash point: 22°(71°F)
Density : 1.200
Refractive Index : 1.5390
Sensitivity : Air Sensitive. Light Sensitive. Store under Nitrogen. Ambient temperatures.
Form : Liquid
Solubility : Soluble in ethanol and ether. Slightly soluble in water.
Literature References
For an example of 2-lithiation, see: J. Med. Chem., 37, 3492 (1994). For other uses of 2-lithiothiazole, see 2-Bromothiazole, A14838.
Applications
Thiazole is used as a flavoring agent and in the preparation of dyes and rubber accelerators. It serves as a component of the vitamin thiamine (B1). It acts as a protected formyl group used in natural product synthesis. It reacts with alkyl lithium and GrignardÂ’s reagent to prepare organometallic complexes. It is involved in the electrophilic aromatic substitution and nucleophilic aromatic substitution at C-5 and C-2 positions respectively. Further, it undergoes alkylation reaction to get thiazolium cation, which is used as a catalyst in the Stetter reaction and the Benzoin condensation. In addition to this, it is involved in the preparation of alagebrium.
Grade Specifications
GHS Hazard and Precautionary Statements
Hazard Statements : H225-H302-H319Highly flammable liquid and vapour.Harmful if swallowed.Causes serious eye irritation.
Precautionary Statements : P210-P261-P280f-P305+P351+P338Keep away from heat/sparks/open flames/hot surfaces. – No smoking.Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective clothing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Other References:Beilstein: 103852Merck: 14,9307UN#: UN1993
| Pakage | 1g, 25g, 5g |
|---|---|
| brand | Alfa Aesar |
