[L12570] CAS 109-78-4 | 3-Hydroxypropionitrile, 97%

CAS : 109-78-4
MDL : MFCD00002826
EINECS : 203-704-8

Other name :

2-CyanoethanolEthylene cyanohydrin

Chemical Properties

Formula : C3H5NO
Formula weight : 71.08
Melting Point : -46°
Boiling Point : 227-228°
Flash point : 128°(262°F)
Density : 1.041
Refractive Index : 1.4250
Sensitivity : Ambient temperatures.
Form : Liquid
Solubility : Fully miscible in water.

Literature References

Protection of carboxylic acids as 2-cyanoethyl esters can be accomplished by DCC-DMAP coupling. The esters can be cleaved with TBAF in DMF-THF: Chem. Pharm. Bull., 42, 147 (1994), or Na2S in methanol: Chem. Pharm. Bull., 42, 1579 (1994). Can also be used to protect the phosphate group, by condensation with 2,4,6-Triisopropyl­benzenesulfonyl­ chloride, A11458: Chem. Pharm. Bull., 25, 2844 (1977), or DCC: J. Am. Chem. Soc., 83, 159 (1961). Cleavage can be effected with an amine: Tetrahedron Lett., 23, 5119 (1982), ammonia: J. Org. Chem., 59, 2482 (1994); Tetrahedron Lett., 35, 4311 (1994), or TBAF: Tetrahedron Lett., 1255 (1976). Precursor of 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a reagent for the phosphorylation of nucleosides: Synthesis, 831 (1980); see 2,2,2-Trichloroethanol, L08163.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.Other References:Beilstein: 635773Merck: 14,3794

Grade Specifications

Grade Specifications

Hazard Statements : H315-H319-H335Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P261-P305+P351+P338-P302+P352-P321-P405-P501aAvoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF ON SKIN: Wash with plenty of soap and water.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.