[L15012] CAS 4039-32-1 | Lithium bis(trimethylsilyl)amide, 20% (ca 1.06M) soln. in THF/ethylbenzene, packaged in resealable septum cap bottle | Alfa
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Brand: Alfa Aesar
4039-32-1 | C6H18LiNSi2 | lithium bis(trimethylsilyl)amide
Chemical Identifiers
CAS
4039-32-1
Molecular Weight (g/mol)
167.33
Synonym
lithium bis(trimethylsilyl)amide
SMILES
[Li+].C[Si](C)(C)[N-][Si](C)(C)C
InChI Key
YNESATAKKCNGOF-UHFFFAOYSA-N
Molecular Formula
C6H18LiNSi2
IUPAC Name
lithium(1+) bis(trimethylsilyl)azanide
Specifications
Appearance (Color)
Clear or slightly hazy, yellow to brown
Form
Liquid
Assay (unspecified)
18-22% active base as LHMDS
설명
Lithium bis(trimethylsilyl)amide is used in generating enolates for preparing lactone precursors, pyranones, and cyclohexanes. It is used to catalyze the addition of phosphine P-H bonds to carbodiimides leading to phosphaguanidines and in a novel three-step synthesis of disubstituted 1,2,5-thiadiazoles. It is also used in the lithiation of ethyl acetate and in the stereospecific Wadsworth-Emmons synthesis of fluoroalkenes from (E)- and (Z)-fluorovinyl sulfones.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Lithium bis(trimethylsilyl)amide is used in generating enolates for preparing lactone precursors, pyranones, and cyclohexanes. It is used to catalyze the addition of phosphine P-H bonds to carbodiimides leading to phosphaguanidines and in a novel three-step synthesis of disubstituted 1,2,5-thiadiazoles. It is also used in the lithiation of ethyl acetate and in the stereospecific Wadsworth-Emmons synthesis of fluoroalkenes from (E)- and (Z)-fluorovinyl sulfones.
Lithium bis(trimethylsilyl)amide is used in generating enolates for preparing lactone precursors, pyranones, and cyclohexanes. It is used to catalyze the addition of phosphine P-H bonds to carbodiimides leading to phosphaguanidines and in a novel three-step synthesis of disubstituted 1,2,5-thiadiazoles. It is also used in the lithiation of ethyl acetate and in the stereospecific Wadsworth-Emmons synthesis of fluoroalkenes from (E)- and (Z)-fluorovinyl sulfones.
Solubility
Reacts with water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas. Incompatible with oxidizing agents.
Other References:
UN Number:UN2924Beilstein:8136861
GHS Hazard and Precautionary Statements
Hazard Statements:H225-H302-H304-H314-H335-H336-H351
GHS H StatementH225-H314-H351-H335 Highly flammable liquid and vapor.Causes severe skin burns and eye damage.Suspected of causing cancer.May cause respiratory irritation.
Precautionary Statements:P201-P202-P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P281-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c
Risk & Safety
TSCA:Yes
경고:RUO – Research Use Only
CAS4039-32-1FORMULAC6H18LiNSi2HAZARD CLASS3EINECS223-725-6MDLMFCD00008261PACKAGING GROUPII
| Pakage | 100ml, 500ml |
|---|---|
| brand | Alfa Aesar |
