[L17117] CAS 62778-11-4 | Hydrogen fluoride pyridine complex, ca 70% HF

CAS : 62778-11-4
UN# : UN1790
MDL : MFCD00012436
Hazard Class : 8
Packing Group : I

Other name :

Olah’s ReagentPyridinium poly(hydrogen fluoride)

Chemical Properties

Boiling Point : 50°/1mm
Density : 1.100
Sensitivity : Store under Nitrogen. Keep Cold. Moisture Sensitive.
Form : Liquid

Literature References

Convenient form of anhydrous HF, showing increased reactivity in many reactions: J. Org. Chem., 44, 3872 (1979). Alkenes and alkynes undergo hydrofluorination; in the presence of NIS or NBS, iodo- or bromofluorination occurs: Synthesis, 779 (1973). Secondary and tertiary alcohols are converted to alkyl fluorides: Synthesis, 653 (1974). Diazotization of ɑ-amino acids in the presence of the reagent provides good yields of ɑ-fluoro acids: Synthesis, 654 (1974). Reaction with aryldiazonium salts or triazenes leads to aryl fluorides, providing a convenient alternative to the Balz-Schiemann reaction (see Tetrafluoroboric acid, L14037): J. Am. Chem. Soc., 97, 208 (1975); J. Chem. Soc., Chem. Commun., 914 (1979); Bull. Chem. Soc. Jpn., 63, 2058 (1990). In combination with nitrosonium tetrafluorborate, ketoximes are converted to gem-difluorides: Synlett, 425 (1994). For use in electrophilic electrochemical fluorination, see: J. Fluorine Chem., 83, 31 (1997). The reagent is also widely applied to the cleavage of a variety of silyl protecting groups including TBDMS, TES, TBDPS and TIPS: Synthesis, 453 (1986); J. Am .Chem. Soc., 112, 7001 (1990); for further discussion see: P. Kocienski, Protecting Groups, Thieme, Stuttgart (1994).

Notes

Moisture sensitive. Store in cool place. Incompatible with strong bases, alkali metals, strong oxidizing agents, metals and strong acids. It reacts violently with water.Other References:Beilstein: 4750151Merck: 14,6821UN#: UN1790

Grade Specifications

Grade Specifications

Hazard Statements : H300-H310-H330-H314-H318Fatal if swallowed.Fatal in contact with skin.Fatal if inhaled.Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements : P260-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment is urgent (see label).Rinse mouth.Remove/Take off immediately all contaminated clothing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.